This is a sakura themed installment of the monthly visuals they have been releasing for this series leading up to the April premiere. You can see all the visuals they have released so far on the official website here.
Series premieres this April and is a re-adaptation of the story instead of a continuation of the previous series. Synopsis from AniList:
Lawrence is a traveling merchant selling various goods from a horse-drawn cart. One day, he arrives at a village and meets a beautiful girl with the ears and tail of an animal! Her name is Holo the Wisewolf and she brings bountiful harvests. She wishes to return to her homeland, and Lawrence offers to take her. Now, the once-lonely merchant and the once-lonely wisewolf begin their journey north.
The design on these key visuals are so solid, it’s like that’s what Holo was supposed to look like. Not putting down the original artwork of the anime, but this is peak Spice & Wolf character design.