Funnily enough, I block very liberally.
I find that having the option to block by keywords, instances, communities and users let’s me curate my feed exactly as I want. What I wouldn’t want is for the blocks to be too broad of a brush (like in the users of instances example), which would lead to missing out on valuable conversations.
Oh shit, I remember watching Gumbo Slice backyard street fights back in the day. Didn’t realize this was meant to be him!